Women's Hormone Test Panel — Expanded

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Dehydroepiandrosterone Sulfate, DHEA SO4, DHEA Sulfate Immunoassay, DHEAS, Transdehydroandrosterone

DHEA SULFATE

DHEA-sulfate test measures the amount of DHEA-sulfate in the blood. DHEA-sulfate is a weak male hormone (androgen) produced by the adrenal gland in both men and women.

Estradiol

Estradiol (estradiol-17 beta, E2) is part of an estrogen that is a group of steroids that regulate the menstrual cycle and function as the main female sex hormones. Estrogens are responsible for the development of female sex organs and secondary sex characteristics and are tied to the menstrual cycle and pregnancy. They are considered the main sex hormones in women and are present in small quantities in men. Estradiol (E2) is the predominant form of estrogen and is produced primarily in the ovaries with additional amounts produced by the adrenal glands in women and in the testes and adrenal glands in men. Estradiol levels are used in evaluating ovarian function. Estradiol levels are increased in cases of early (precocious) puberty in girls and gynecomastia in men. Its main use has been in the differential diagnosis of amenorrhea – for example, to determine whether the cause is menopause, pregnancy, or a medical problem. In assisted reproductive technology (ART), serial measurements are used to monitor follicle development in the ovary in the days prior to in vitro fertilization. Estradiol is also sometimes used to monitor menopausal hormone replacement therapy.

Also known as: Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH), Follicle Stimulating Hormone and Luteinizing Hormone

Fsh

Lh

Also known as: Progesterone Immunoassay

Progesterone

Serum progesterone is a test to measure the amount of progesterone in the blood. Progesterone is a hormone produced mainly in the ovaries. In women, progesterone plays a vital role in pregnancy. After an egg is released by the ovaries (ovulation), progesterone helps make the uterus ready for implantation of a fertilized egg. It prepares the womb (uterus) for pregnancy and the breasts for milk production. Men produce some amount of progesterone, but it probably has no normal function except to help produce other steroid hormones.

Also known as: PRL

Prolactin

Prolactin is a hormone produced by the anterior portion of the pituitary gland, a grape-sized organ found at the base of the brain. Prolactin secretion is regulated and inhibited by the brain chemical dopamine. Normally present in low amounts in men and non-pregnant women, prolactin's primary role is to promote lactation (breast milk production). Prolactin levels are usually high throughout pregnancy and just after childbirth. During pregnancy, the hormones prolactin, estrogen, and progesterone stimulate breast milk development. Following childbirth, prolactin helps initiate and maintain the breast milk supply. If a woman does not breastfeed, her prolactin level soon drops back to pre-pregnancy levels. If she does nurse, suckling by the infant plays an important role in the release of prolactin. There is a feedback mechanism between how often the baby nurses and the amount of prolactin secreted by the pituitary as well as the amount of milk produced. Another common cause of elevated prolactin levels is a prolactinoma, a prolactin-producing tumor of the pituitary gland. Prolactinomas are the most common type of pituitary tumor and are usually benign. They develop more frequently in women but are also found in men. Problems resulting from them can arise both from the unintended effects of excess prolactin, such as milk production in the non-pregnant woman (and rarely, man) and from the size and location of the tumor. If the anterior pituitary gland and/or the tumor enlarge significantly, it can put pressure on the optic nerve, causing headaches and visual disturbances, and it can interfere with the other hormones that the pituitary gland produces. In women, prolactinomas can cause infertility and irregularities in menstruation; in men, these tumors can cause a gradual loss in sexual function and libido. If left untreated, prolactinomas may eventually damage the tissues around them.

Also known as: Free T3, FT3, T3 Free

T3, Free

This test measures the amount of triiodothyronine, or T3, in the blood.

Also known as: Free T4, FT4, T4 Free

T4, Free

The free T4 test is not affected by protein levels. Since free T4 is the active form of thyroxine, the free T4 test is may be a more accurate reflection of thyroid hormone function.

Also known as: Testosterone, Testosterone Total LCMSMS, Testosterone, Total

TESTOSTERONE, TOTAL,

A testosterone test measures the amount of the male hormone, testosterone, in the blood. Both men and women produce this hormone. In males, the testicles produce most of the testosterone in the body. Levels are most often checked to evaluate signs of low testosterone: In boys -- early or late puberty and in men -- impotence, low level of sexual interest, infertility, thinning of the bones In females, the ovaries produce most of the testosterone and levels are most often checked to evaluate signs of higher testosterone levels, such as: decreased breast size, excess hair growth, increased size of the clitoris. irregular or absent menstrual periods and male-pattern baldness or hair thinning.

Also known as: Anti-Thyroid Microsomal Antibody, Anti-TPO, Thyroid Peroxidase Antibodies TPO, TPO

Thyroid Peroxidase

Also known as: Thyroid Stimulating Hormone, Thyroid Stimulating Hormone (TSH), Thyrotropin

TSH

A TSH test is a lab test that measures the amount of thyroid stimulating hormone (TSH) in your blood. TSH is produced by the pituitary gland. It tells the thyroid gland to make and release thyroid hormones into the blood.

TSH

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The Women's Hormone Test Panel — Expanded panel contains 10 tests with 12 biomarkers .

The Women's Hormone Test Panel — Expanded is a comprehensive diagnostic tool that evaluates a broader range of hormones and thyroid function markers to provide a more detailed assessment of a woman's endocrine health. Hormones are critical for regulating processes such as reproduction, metabolism, mood, and energy levels. This expanded panel measures additional hormones and thyroid antibodies, offering a deeper understanding of imbalances that may contribute to symptoms such as infertility, fatigue, weight changes, irregular menstrual cycles, or mood disturbances. It is particularly valuable for women experiencing complex symptoms that may involve multiple hormonal pathways.

When and Why the Women's Hormone Test Panel — Expanded May Be Ordered

The Women's Hormone Test Panel — Expanded is ordered when symptoms suggest a more complex hormonal or thyroid imbalance. Healthcare providers may recommend this panel for women experiencing persistent fatigue, unexplained weight gain or loss, fertility issues, irregular menstrual cycles, hair loss, mood disorders, or menopausal symptoms. It is also particularly useful for diagnosing autoimmune thyroid disorders, such as Hashimoto's thyroiditis, as well as adrenal or ovarian dysfunction. Women undergoing hormone replacement therapy or treatment for conditions like polycystic ovary syndrome (PCOS) may also benefit from this panel to monitor their hormonal status.

This panel provides a more detailed evaluation compared to the basic version, particularly for patients with suspected thyroid dysfunction, adrenal abnormalities, or progesterone-related issues.

What the Women's Hormone Test Panel — Expanded Checks For

The Women's Hormone Test Panel — Expanded measures key hormones and thyroid-related markers that regulate a variety of bodily functions. Each component offers valuable insights into the endocrine system and thyroid health:

DHEA

DHEA is an adrenal steroid hormone that serves as a precursor to sex hormones like estrogen and testosterone. It is essential for energy, mood, and hormone production. Abnormal levels can indicate adrenal gland disorders or polycystic ovary syndrome (PCOS).

Estradiol

Estradiol is the primary estrogen in premenopausal women. It regulates menstrual cycles, supports fertility, and maintains secondary sexual characteristics. Low levels may indicate menopause or ovarian dysfunction, while high levels can be linked to estrogen dominance or certain ovarian conditions.

Follicle-Stimulating Hormone (FSH)

FSH stimulates the ovaries to produce follicles and is critical for menstrual cycle regulation and fertility. Elevated FSH levels often signal menopause, while low levels may indicate pituitary dysfunction or ovarian insufficiency.

Luteinizing Hormone (LH)

LH works alongside FSH to regulate ovulation and the menstrual cycle. Abnormal LH levels can indicate conditions such as PCOS, menopause, or primary ovarian failure.

Progesterone

Progesterone is essential for maintaining the uterine lining during the menstrual cycle and supporting early pregnancy. Low progesterone levels may contribute to infertility, recurrent miscarriages, or luteal phase defects.

Prolactin

Prolactin stimulates milk production after childbirth. Elevated prolactin levels outside pregnancy or breastfeeding can indicate pituitary disorders, hypothyroidism, or stress-related conditions.

T3 Free

Free T3 is an active thyroid hormone that regulates metabolism, energy levels, and body temperature. Abnormal levels may indicate hyperthyroidism, hypothyroidism, or issues with thyroid hormone conversion.

T4 Free

Free T4 is another essential thyroid hormone that controls metabolic rate and overall energy production. Abnormal T4 levels can signal thyroid dysfunction, including hypothyroidism and hyperthyroidism.

Testosterone Total

Testosterone is important for energy, muscle maintenance, and libido in women. Elevated levels can indicate PCOS or adrenal disorders, while low levels may contribute to fatigue, low libido, or mood changes.

Thyroid Peroxidase Antibodies (TPO)

TPO antibodies are markers of autoimmune thyroid disease, such as Hashimoto's thyroiditis. Elevated TPO levels suggest an immune response against thyroid tissue, leading to hypothyroidism or thyroid dysfunction.

Thyroid-Stimulating Hormone (TSH)

TSH regulates thyroid hormone production and is a primary marker of thyroid health. Elevated TSH suggests hypothyroidism, while low levels indicate hyperthyroidism or pituitary dysfunction.

Conditions or Diseases the Women's Hormone Test Panel — Expanded Can Detect

The Women's Hormone Test Panel — Expanded can help diagnose a range of conditions, including polycystic ovary syndrome (PCOS), hypothyroidism, hyperthyroidism, Hashimoto's thyroiditis, menopause, adrenal dysfunction, and pituitary disorders. These conditions often share overlapping symptoms, making this expanded panel essential for accurate diagnosis and management.

Polycystic Ovary Syndrome (PCOS)

PCOS is a hormonal disorder characterized by irregular periods, excess hair growth, weight gain, and ovarian cysts. The panel identifies elevated testosterone levels, imbalances in LH and FSH, and abnormal DHEA levels, which are common markers of PCOS. By evaluating these hormones, healthcare providers can confirm the diagnosis and develop targeted treatments to regulate cycles and manage symptoms.

Hypothyroidism

Hypothyroidism occurs when the thyroid gland underproduces thyroid hormones, leading to symptoms like fatigue, weight gain, cold intolerance, and hair loss. Elevated TSH and low free T4 levels are hallmark indicators of hypothyroidism. The panel also measures T3 levels and TPO antibodies to identify autoimmune causes like Hashimoto's thyroiditis.

Hyperthyroidism

Hyperthyroidism involves excessive thyroid hormone production, causing weight loss, rapid heartbeat, and anxiety. Low TSH and elevated T3 and T4 levels help identify hyperthyroidism. Additional markers in the panel allow healthcare providers to determine the underlying cause and guide treatment.

Hashimoto's Thyroiditis

Hashimoto's thyroiditis is an autoimmune disorder where the immune system attacks the thyroid gland, causing hypothyroidism over time. Elevated TPO antibodies in the panel confirm the autoimmune nature of thyroid dysfunction, allowing for proper diagnosis and treatment.

Menopause and Perimenopause

Menopause marks the natural decline of reproductive hormones, leading to symptoms such as hot flashes, mood swings, and sleep disturbances. The panel identifies elevated FSH and LH levels and decreased estradiol and progesterone levels, confirming the transition to menopause.

Adrenal Dysfunction

Adrenal disorders, such as adrenal insufficiency or hyperplasia, impact DHEA levels. Symptoms include fatigue, weight changes, and hormonal imbalances. Evaluating DHEA levels alongside other hormones helps detect adrenal abnormalities and guide further testing or treatment.

Pituitary Disorders

Pituitary dysfunction can cause abnormal levels of prolactin, LH, FSH, and TSH. Elevated prolactin levels may indicate a pituitary tumor or dysfunction, while abnormal LH and FSH levels suggest disruptions in reproductive hormone regulation.

How Healthcare Professionals Use the Results of the Women's Hormone Test Panel — Expanded

Managing Polycystic Ovary Syndrome (PCOS)

Healthcare providers use the results to confirm PCOS and guide treatment. Elevated testosterone and DHEA levels may be managed with medications like anti-androgens or lifestyle interventions to improve symptoms and restore menstrual regularity.

Treating Hypothyroidism

Abnormal TSH, T3, and T4 levels help healthcare providers diagnose hypothyroidism. Treatment typically involves thyroid hormone replacement therapy, such as levothyroxine, to restore normal hormone levels and alleviate symptoms.

Addressing Hyperthyroidism

Low TSH and elevated thyroid hormone levels guide the diagnosis and treatment of hyperthyroidism. Providers may use medications, radioactive iodine, or surgery to normalize thyroid function.

Managing Hashimoto's Thyroiditis

Elevated TPO antibodies confirm autoimmune thyroid disease. Healthcare providers use this information to initiate thyroid hormone replacement therapy and monitor thyroid function over time to prevent complications.

Supporting Women Through Menopause

The panel helps confirm menopause or perimenopause through hormone evaluation. Treatment options, including hormone replacement therapy (HRT) or lifestyle modifications, can be tailored to alleviate symptoms and improve quality of life.

Identifying Adrenal Dysfunction

Abnormal DHEA levels help detect adrenal insufficiency or hyperplasia. Providers may recommend additional adrenal testing or treatments to restore adrenal hormone balance.

Diagnosing Pituitary Disorders

Elevated prolactin levels or abnormal LH, FSH, and TSH levels may prompt further imaging to assess pituitary gland function. Treatments can include medications or surgical intervention, depending on the underlying cause.

Conclusion

The Women's Hormone Test Panel — Expanded provides a comprehensive evaluation of a woman's hormonal and thyroid health, offering valuable insights into complex symptoms and conditions. By measuring critical hormones and thyroid markers, this panel helps diagnose conditions such as PCOS, thyroid dysfunction, menopause, and adrenal or pituitary disorders. Healthcare providers use these results to develop targeted treatments, monitor progress, and improve overall well-being. This expanded panel is an essential tool for women experiencing symptoms of hormonal imbalance or those seeking a deeper understanding of their endocrine health.

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