Interleukin 2 Receptor Test
The Interleukin 2 Receptor (IL-2R) Test evaluates soluble receptor levels in blood, reflecting immune system activation and regulation. Increased IL-2R may be seen in lymphoma, sarcoidosis, autoimmune conditions, and chronic inflammatory disease. This test provides insights into T-cell activation, immune dysregulation, and disease monitoring, helping guide evaluation of systemic immune health.
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The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.
Specimen Type: Serum
Also known as: Interleukin 2 Receptor Eia
INTERLEUKIN 2 RECEPTOR
Interleukin 2 Receptor,
The Interleukin 2 Receptor Test test contains 1 test with 2 biomarkers .
Clinical Use
Assess T-cell activation following transplantation
Assess prognosis in patients with lymphoma
Monitor therapeutic response in patients with hairy cell leukemia
Clinical Background
Elevated levels of soluble IL-2 receptor are detected in AIDS, autoimmune diseases, sarcoidosis, and a variety of leukemias and lymphomas. In HIV-positive individuals, the IL-2 receptor level is elevated during the asymptomatic phase, as well as during persistent generalized lymphadenopathy and symptomatic phases. IL-2 receptor detection may be useful in monitoring HIV and in assessing T-cell activation following transplantation. Elevated IL-2 receptor levels may also have clinical and prognostic significance in patients with malignant lymphoma, non-Hodgkin's lymphoma, B-cell, and undifferentiated lymphomas.
Studies have suggested that IL-2 receptor levels in a broad spectrum of conditions associated with T- or B-cell immune activation offer a rapid and reliable measure of disease activity, response to therapy, and, in some cases, prognosis. Measurement of the soluble IL-2 receptor level is also helpful in assessing therapeutic response in patients with hairy cell leukemia.
Method
Enzyme immunoassay (EIA)
Clinical Significance
Following stimulation by antigen, IL-2R is expressed on all T cells. IL-2R is released by activated cells into the surrounding extracellular fluid. IL2-R is involved in infectious, inflammatory and autoimmune diseases, cancer, and transplantation. IL-2R Antibodies are used therapeutically.
Alternative Name(s)
IL-2 Receptor, CYTOKINE