Hemolytic Anemia Test

Hemolytic anemia is a condition where red blood cells are destroyed faster than the body can replace them. This premature destruction — called hemolysis — can be caused by autoimmune disorders, genetic conditions, certain medications, or infections. People with hemolytic anemia may experience fatigue, jaundice, rapid heartbeat, or dark-colored urine.

Laboratory testing is essential to evaluate red blood cell health, identify possible underlying causes, and guide clinical decision-making. Hemolytic anemia tests help detect abnormal blood cell breakdown, assess markers of red blood cell destruction, and differentiate this condition from other types of anemia.

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The Hemoglobinopathy Evaluation screens for abnormal hemoglobin variants and thalassemias by analyzing the types and amounts of hemoglobin in blood. This test helps diagnose sickle cell disease, beta thalassemia, alpha thalassemia, and other inherited disorders affecting red blood cells. Doctors use it to investigate anemia, unexplained blood abnormalities, or family history of hemoglobinopathies, guiding diagnosis, genetic counseling, and treatment planning.

Also Known As: Hemoglobin Evaluation Test, Hb ELP Test, Hb IEF, Sickle Cell Screen Test, Hemoglobin Fraction Test, Hemoglobinopathies Test

The Complete Blood Count with Differential and Platelets Test is a comprehensive blood test that checks red blood cells, white blood cells, hemoglobin, hematocrit, and platelets. The differential analyzes types of white blood cells to detect infections, anemia, clotting abnormalities, immune conditions, and certain cancers. This essential test is often ordered for routine health exams, diagnosis, and monitoring treatment progress.

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Also Known As: CBC Test, CBC with Differential and Platelets Test, CBC w/Diff and Platelets Test, Full Blood Count Test, Complete Blood Count Test

The ABO Group and Rh Type Test identifies a person’s blood type by determining ABO group (A, B, AB, or O) and Rh factor (positive or negative). This test is essential before blood transfusions, organ transplants, or pregnancy care, where compatibility is critical. Doctors use it to prevent transfusion reactions, manage Rh incompatibility in pregnancy, and ensure safe medical procedures. Results provide vital insight into blood type and overall health management.

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Also Known As: Blood Type Test

The Glucose-6-Phosphate Dehydrogenase (G6PD) Test measures enzyme activity to detect G6PD deficiency, a genetic condition that can lead to hemolytic anemia when exposed to certain foods, infections, or medications. Doctors order this test to assess unexplained anemia, jaundice, or family history of G6PD deficiency. Results help identify individuals at risk for red blood cell breakdown, guiding treatment, prevention, and safe medication use.

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Also Known As: Glucose-6-Phosphate Dehydrogenase Test, G6PD Enzyme Test, G6PD Deficiency Test

The Hemoglobin Test measures the amount of hemoglobin in blood, the protein that carries oxygen to tissues. Low hemoglobin may indicate anemia, blood loss, or nutritional deficiencies, while high levels may suggest dehydration, lung disease, or bone marrow disorders. Doctors order this test to evaluate fatigue, weakness, or shortness of breath. Results provide key insight into oxygen transport, red blood cell health, and overall hematologic function.

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Also Known As: Hgb Test

The Reticulocyte Count Test measures immature red blood cells (reticulocytes) to evaluate bone marrow function and red cell production. High levels may indicate blood loss, hemolytic anemia, or recovery from treatment, while low levels may suggest bone marrow failure, nutritional deficiencies, or chronic disease. Doctors use this test to assess anemia, monitor therapy, or track recovery. Results provide key insight into red blood cell health and overall hematologic function.

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Also Known As: Retic Count Reticulocyte Percent Test, Reticulocyte Index Test, Corrected Reticulocyte Test, Reticulocyte Production Index Test, RPI Test

The DNA (ds) Antibody Test detects double-stranded DNA antibodies, often linked to systemic lupus erythematosus (SLE) and other autoimmune diseases. High levels may indicate lupus activity, kidney involvement, or autoimmune flare-ups. Doctors order this test for patients with joint pain, fatigue, rash, or suspected connective tissue disease. Results provide critical insight for diagnosing lupus, monitoring disease progression, and guiding treatment decisions.

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The Erythropoietin (EPO) Test measures levels of erythropoietin, a hormone made by the kidneys that stimulates red blood cell production. Abnormal levels may indicate anemia, chronic kidney disease, or bone marrow disorders. Elevated EPO can also occur with low oxygen levels or tumors. Doctors order this test for patients with unexplained fatigue, shortness of breath, or abnormal blood counts. Results help guide diagnosis, treatment, and monitoring of anemia-related conditions.

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Also Known As: Erythropoietin Test

The Comprehensive Metabolic Panel (CMP) Test measures 21 markers to assess metabolic health, liver and kidney function, and electrolyte balance. It includes glucose, calcium, sodium, potassium, chloride, CO2, albumin, globulin, A/G ratio, total protein, bilirubin, ALP, AST, ALT, BUN, creatinine, BUN/creatinine ratio, and eGFR. The CMP helps detect diabetes, liver or kidney disease, and supports routine screening and chronic condition monitoring.

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Also Known As: CMP Test, Chemistry Panel Test, Chem Test, Chem 21 Test, Chem 14 Test 

The Babesia microti IgG IgM Antibodies Test detects antibodies to the parasite that causes babesiosis, a tick-borne infection affecting red blood cells. IgM indicates recent or active infection, while IgG suggests past or ongoing exposure. Doctors use this test to diagnose babesiosis in patients with fever, chills, anemia, or fatigue, and to differentiate it from Lyme disease or other tick-borne illnesses for accurate treatment.

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The Bilirubin Direct Test measures conjugated bilirubin in the blood to assess liver function and bile duct health. Elevated levels may indicate hepatitis, cirrhosis, gallstones, or bile duct obstruction, while low levels are generally normal. Doctors order this test for patients with jaundice, fatigue, or suspected liver disease. Results help diagnose and monitor liver disorders, guide treatment decisions, and evaluate overall hepatic and biliary health.

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Also Known As: Direct Bilirubin Test

The Fractionated Bilirubin Test separates total bilirubin into direct and indirect forms to assess liver and blood health. Elevated direct bilirubin may point to hepatitis, cirrhosis, or bile duct obstruction, while elevated indirect levels can signal hemolytic anemia or inherited disorders. Doctors order this test for jaundice, anemia, or suspected liver conditions. Results help guide diagnosis, treatment, and monitoring of liver and blood disorders.

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Also Known As: Fractionated Bilirubin Test

The Bilirubin Total Test measures the overall level of bilirubin in blood to assess liver function, red blood cell breakdown, and bile duct health. Elevated bilirubin may cause jaundice and indicate hepatitis, cirrhosis, gallstones, or hemolytic anemia. Doctors order this test for patients with yellowing skin, fatigue, or abnormal liver results. Results provide essential insight into liver disease, blood disorders, and bile flow problems, guiding diagnosis and treatment.

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Also Known As: Total Bilirubin Test

The Cardiolipin IgG IgA IgM Antibodies Test detects autoantibodies linked to antiphospholipid syndrome (APS), a disorder that increases the risk of blood clots, stroke, and pregnancy complications. Measuring IgG, IgA, and IgM helps identify abnormal immune responses. Doctors use this test to evaluate patients with unexplained clotting, recurrent miscarriages, or autoimmune disease, guiding diagnosis and treatment of APS and related conditions.

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Panel Contains Test: Anticardiolipin Antibodies Test, aCL Antibody Test, Cardiolipin Antibodies Test

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The Cardiolipin IgA Antibody Test detects IgA antibodies to cardiolipin, helping assess clotting disorders, autoimmune disease, and vascular complications. High levels are often linked to antiphospholipid syndrome, pregnancy loss, or thrombotic conditions. This test provides insight into immune activity, coagulation balance, and systemic disorders influenced by antibody-mediated vascular dysfunction.

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The Cardiolipin IgG Antibody Test detects IgG antibodies to cardiolipin, often associated with autoimmune disease. Abnormal results may indicate antiphospholipid syndrome, blood clotting disorders, or pregnancy complications. This test provides insight into thrombotic risk, vascular health, systemic inflammation, and immune activity linked to autoimmune conditions and antibody-mediated disease.

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The Cardiolipin IgM Antibody Test measures IgM antibodies linked to antiphospholipid syndrome and autoimmune disorders. It helps evaluate unexplained blood clots, recurrent miscarriages, or abnormal clotting events. By detecting immune system activity against phospholipids, this test supports the assessment of vascular health, autoimmune activity, and risks related to thrombosis or systemic lupus erythematosus.

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The Direct Antiglobulin Test with Reflex to Anti C3 and Anti IgG evaluates immune-mediated red blood cell destruction by detecting antibodies or complement proteins. Abnormal findings may suggest autoimmune hemolytic anemia, drug-induced hemolysis, or transfusion reaction. Reflex testing helps distinguish complement activation from IgG involvement, offering insight into immune regulation and hematologic health.

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Also Known As: Direct Coombs Test, Coombs Direct Test, DAT Test

The Hepatic Function Panel Test measures liver enzymes, proteins, and bilirubin to assess liver health and function. It includes ALT, AST, ALP, albumin, total protein, and bilirubin levels. Abnormal results may indicate hepatitis, cirrhosis, fatty liver, or bile duct problems. Doctors use this test to investigate jaundice, nausea, abdominal pain, or fatigue and to monitor liver disease, alcohol use, or medication side effects affecting liver function.

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Also Known As: Liver Function Panel Test, LFT

The Liver Function Panel, also known as a Hepatic Function Panel, measures proteins, enzymes, and bilirubin to assess liver health and function. It helps detect liver disease, monitor liver conditions, and evaluate the effects of medications or other factors on liver performance.

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Also Known As: Hepatic Function Panel Test, HFP Test

The Obstetric Panel is a prenatal blood test panel that screens for conditions affecting pregnancy and maternal health. It typically includes a Complete Blood Count, blood typing with Rh factor, antibody screen, and infectious disease testing such as hepatitis B, syphilis, rubella, and HIV. Doctors use this panel in early pregnancy to evaluate overall health, identify risks, and ensure safe monitoring for both mother and baby.


The Unstable Hemoglobin Test detects abnormal hemoglobin variants prone to instability and breakdown, which can cause hemolytic anemia. Unstable hemoglobins may lead to premature red blood cell destruction, anemia, jaundice, or splenomegaly. This test helps identify hereditary hemoglobin disorders, supports differential diagnosis of unexplained hemolysis, and provides insight into genetic causes of red cell fragility.

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Have you been feeling fatigued recently? Or maybe you’ve been feeling feverish, confused, dizzy, or weak. Perhaps there are signs of a serious underlying condition, such as an increased heart rate or dark urine.

If you’ve been experiencing these symptoms, you might be suffering from hemolytic anemia.

While this can be worrying, you can, fortunately, identify the problem and treat it accordingly with lab tests for hemolytic anemia.

In this article, we’ll review everything you need to know about hemolytic anemia and how getting a lab test can help you.

Finally, you can find out if you have hemolytic anemia and get the treatment you need to be healthy. Read on to learn more.

What Is Hemolytic Anemia?

Hemolytic anemia is a condition in which your red blood cells are being destroyed faster than they can be made. Your red blood cells have an essential mission, to carry oxygen from your lungs through your body ... See more