Ulta Lab Tests

Cortisol, LC/MS, Saliva, 3 Samples

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The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

CORTISOL, SALIVA SAMPLE 1

CORTISOL, SALIVA SAMPLE 2

CORTISOL, SALIVA SAMPLE 3

DRAW DATE 1

DRAW TIME 1

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The Cortisol, LC/MS, Saliva, 3 Samples test contains 1 test with 5 biomarkers .

The 3 Sample Cortisol Saliva Test is a non-invasive diagnostic tool used to measure the levels of cortisol in saliva at three different times throughout the day. Cortisol is a steroid hormone produced by the adrenal glands in response to stress and follows a diurnal rhythm, typically peaking in the morning and gradually declining throughout the day. This test helps in assessing the function of the adrenal glands and the body's stress response system.

Collection Times and Procedure: Your physician will guide you on the exact times to collect cortisol samples, as these are crucial for accurate results. Here are general guidelines based on the number of specimens required:

Three Specimens: Saliva

  • Morning (8 AM)
  • Noon (12 PM)
  • Afternoon (4 PM)

When and Why a 3 Sample Cortisol Saliva Test May Be Ordered

This test may be ordered for several reasons:

  1. Assessment of Adrenal Function: To evaluate if the adrenal glands are producing appropriate levels of cortisol, which is crucial for managing stress and maintaining metabolic functions.
  2. Diagnosis of Adrenal Disorders: Such as Addison's disease (adrenal insufficiency) or Cushing's syndrome (overproduction of cortisol).
  3. Chronic Fatigue and Stress-Related Conditions: In patients experiencing symptoms like chronic fatigue, unexplained weight changes, depression, or anxiety.
  4. Monitoring Treatment Efficacy: For patients undergoing treatment for adrenal dysfunction or stress-related conditions.

What a 3 Sample Cortisol Saliva Test Checks For

The test measures the cortisol levels in saliva collected at three specific times during the day, typically in the morning (around waking time), mid-day, and evening. This pattern helps assess:

  • Morning Peak: Cortisol levels should be highest in the morning upon waking.
  • Mid-Day Level: Levels should start to decline but remain detectable.
  • Evening Level: Cortisol levels should be the lowest, preparing the body for sleep.

By comparing these samples, healthcare providers can determine if cortisol levels follow the expected diurnal rhythm and if the adrenal glands are functioning properly.

Additional Lab Tests Ordered Alongside a 3 Sample Cortisol Saliva Test

Depending on the clinical scenario, doctors may order additional tests to complement the cortisol assessment:

  • ACTH (Adrenocorticotropic Hormone) Test: To measure the hormone that stimulates cortisol production, providing insights into pituitary-adrenal function.
  • DHEA-S (Dehydroepiandrosterone Sulfate) Test: To evaluate the balance between adrenal androgen production and cortisol.
  • Thyroid Function Tests: Including TSH, Free T3, and Free T4, as thyroid function can influence cortisol metabolism.
  • Comprehensive Metabolic Panel (CMP): To check overall metabolic function and organ health.
  • Complete Blood Count (CBC): To detect possible infections or other underlying conditions.

How Health Care Providers Use the Results of a 3 Sample Cortisol Saliva Test

Healthcare providers use the results to:

  1. Diagnose Adrenal Disorders: Abnormal cortisol patterns can indicate adrenal insufficiency or hyperfunction, guiding further diagnostic and therapeutic steps.
  2. Assess Stress Response: Identifying dysregulation in cortisol production helps in understanding and managing chronic stress and related conditions.
  3. Tailor Treatment Plans: Results can inform the need for hormone replacement therapy, lifestyle modifications, or stress management interventions.
  4. Monitor Treatment Progress: For patients undergoing treatment for adrenal dysfunction, repeated testing can help track the effectiveness of the intervention and adjust treatment plans accordingly.

The 3 Sample Cortisol Saliva Test is an essential diagnostic tool for evaluating adrenal function and the body's stress response. By measuring cortisol levels at three key times during the day, this test provides valuable insights into the diurnal rhythm of cortisol production and identifies potential dysfunctions. Alongside other diagnostic tests, it helps healthcare providers diagnose adrenal disorders, assess chronic stress, and tailor effective treatment plans, ultimately supporting overall health and well-being.

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