Adrenal Stress Tests (Stress & Fatigue)

The 17-Hydroxypregnenolone Test measures levels of this adrenal steroid precursor in the blood to help evaluate adrenal gland and steroid hormone function. Abnormal results may indicate congenital adrenal hyperplasia, enzyme deficiencies, or adrenal disorders affecting cortisol and androgen production. This test provides valuable insight into hormonal balance and supports the investigation of endocrine and metabolic health conditions.

The 17-Hydroxyprogesterone (17-OHP) Test measures levels of 17-OHP, a hormone made by the adrenal glands, to help diagnose congenital adrenal hyperplasia (CAH) and other adrenal disorders. Elevated levels may indicate enzyme deficiencies affecting cortisol production, while low levels can suggest adrenal insufficiency. Doctors order this test for infants with ambiguous genitalia or adults with irregular periods, infertility, or abnormal androgen symptoms.

The 21-Hydroxylase Antibody Test detects autoantibodies that target the adrenal enzyme 21-hydroxylase, often linked to autoimmune Addison’s disease and adrenal insufficiency. A positive result suggests adrenal gland damage caused by immune attack. Doctors use this blood test to confirm suspected Addison’s disease, evaluate unexplained fatigue or low cortisol, and monitor patients at risk for autoimmune polyglandular syndromes or adrenal failure.

The ACTH Test measures adrenocorticotropic hormone in blood to evaluate pituitary and adrenal gland function. Abnormal ACTH levels may indicate Cushing’s syndrome, Addison’s disease, adrenal tumors, or pituitary disorders. Doctors order this test to investigate symptoms such as fatigue, weight changes, weakness, or high blood pressure. Results provide vital insight into endocrine health, cortisol regulation, and adrenal-pituitary balance.

The Aldosterone 24 Hour Urine Test evaluates adrenal hormone output across 24 hours, offering information about blood pressure regulation, fluid balance, and electrolyte control. Elevated or low levels may suggest primary aldosteronism, adrenal tumors, or secondary hypertension. This test supports assessment of kidney function, cardiovascular health, and endocrine disorders linked to aldosterone imbalance.

The ANA Screen IFA with Reflex to Titer and Pattern Test detects antinuclear antibodies in blood to evaluate autoimmune activity. If positive, further testing identifies antibody concentration (titer) and fluorescence pattern, helping diagnose conditions like lupus, rheumatoid arthritis, or Sjögren’s syndrome. Doctors order this test to investigate symptoms such as joint pain, fatigue, rash, or swelling and to guide treatment for autoimmune and connective tissue disorders.

The ANA IFA Panel Comprehensive screens for autoimmune disorders by detecting antinuclear antibodies and specific markers including dsDNA, Sm, Sm/RNP, Scl-70, and Sjögren’s SS-A/SS-B. Doctors order this panel for patients with joint pain, rash, fatigue, or suspected lupus, scleroderma, or Sjögren’s syndrome. Results provide critical insight into autoimmune activity, helping confirm diagnosis, monitor disease progression, and guide treatment decisions.

The Androstenedione Test measures levels of this steroid hormone, produced by the adrenal glands and ovaries or testes, which converts into testosterone and estrogen. Abnormal results may indicate PCOS, adrenal tumors, congenital adrenal hyperplasia, or ovarian/testicular disorders. Doctors order this test for irregular periods, infertility, excess hair growth, or early puberty. Results provide key insight into hormone balance, adrenal function, and reproductive health.

The Antiadrenal Antibody Screen With Reflex To Titer detects antibodies targeting adrenal cortex tissue, which may signal autoimmune adrenal disease. Positive results are reflexed to titer to confirm antibody levels. This test supports diagnosis of Addison’s disease, autoimmune adrenalitis, or endocrine disorders, offering insight into adrenal gland health, immune system activity, and hormone regulation.

The Calcium Micronutrient Test measures calcium levels in the blood to assess nutritional status and detect imbalances. Calcium is essential for strong bones and teeth, muscle contraction, nerve signaling, and heart function. This test helps identify deficiencies, excess, or issues with absorption and metabolism, supporting diagnosis and management of bone health, hormonal balance, and overall wellness.

Patient must be 18 years of age or older.

The Calcium Test measures calcium levels in blood to assess bone health, parathyroid function, and metabolic balance. Abnormal levels may indicate bone disease, parathyroid disorders, kidney disease, or certain cancers. Both low and high calcium can cause muscle spasms, weakness, or irregular heartbeat. Doctors order this test to monitor osteoporosis, kidney stones, or endocrine disorders. Results provide essential insight into bone, nerve, and overall metabolic health.

The Heavy Metals Micronutrients Blood Test Panel measures levels of arsenic, cadmium, cobalt, lead, and mercury to assess exposure and potential toxicity. These metals, found in the environment, food, or workplaces, can affect the nervous system, kidneys, bones, and overall health. This panel helps detect harmful accumulation, guide treatment, and monitor risks from environmental or occupational exposure.

Patient must be 18 years of age or older.

The Candida Albicans (M5) IgE Test measures IgE antibody response to Candida albicans, a common yeast that can trigger allergic reactions. Elevated IgE may indicate sensitivity linked to respiratory, skin, or digestive symptoms. Physicians use this test to identify potential allergic responses, distinguish yeast-related immune activity, and guide evaluation of conditions affecting allergy, inflammation, or overall immune health.

The Candida Albicans IgG, IgA, IgM Antibodies Test detects immune response to Candida albicans, a yeast that can cause fungal infections. Measuring all three antibodies helps identify recent, chronic, or past exposure. Doctors order this test for patients with recurrent yeast infections, digestive issues, fatigue, or weakened immunity. Results provide valuable insight into fungal overgrowth, guiding diagnosis, treatment, and monitoring of candidiasis or systemic infection.

The Cortisol Saliva 4 Samples Test measures cortisol levels at four points during the day to assess adrenal gland function and circadian rhythm. Abnormal patterns may indicate adrenal insufficiency, Addison’s disease, Cushing’s syndrome, or chronic stress. Because saliva reflects active hormone levels, this noninvasive test is ideal for evaluating diurnal cortisol changes, supporting diagnosis, and guiding treatment for endocrine and stress-related disorders.

The Cortisol Test with 2 specimens measures adrenal gland function by evaluating cortisol levels at two collection times. Tracking changes in this stress hormone helps assess adrenal performance, circadian rhythm, and the body’s stress response, while offering insight into conditions such as adrenal insufficiency, Cushing’s syndrome, Addison’s disease, and overall endocrine balance.

The Cortisol Test with 3 specimens measures adrenal gland function by evaluating cortisol levels at three collection times. Monitoring this stress hormone helps assess circadian rhythm, adrenal performance, and daily hormone balance, while providing insight into adrenal insufficiency, Addison’s disease, Cushing’s syndrome, and overall endocrine and metabolic health.

The Cortisol AM Test measures morning cortisol levels in blood to evaluate adrenal gland function and stress response. Cortisol peaks in the morning, making this test critical for detecting adrenal insufficiency (Addison’s disease), Cushing’s syndrome, or other hormone imbalances. Doctors also use it to investigate fatigue, weight changes, or high blood pressure. This test provides important insight into endocrine health, metabolism, and long-term stress regulation.

The Cortisol Free 24-Hour Urine with Creatinine Test measures cortisol excreted in urine over 24 hours, with creatinine used to validate collection. Elevated cortisol may indicate Cushing’s syndrome, while low levels can suggest Addison’s disease or adrenal insufficiency. Doctors order this test for patients with obesity, fatigue, high blood pressure, or abnormal hormone symptoms. Results provide critical insight into adrenal gland function and hormone regulation.

The Cortisol PM Test measures afternoon cortisol levels to evaluate adrenal and pituitary function. Cortisol normally drops later in the day, so abnormal results may indicate Cushing’s syndrome, adrenal insufficiency (Addison’s disease), or hormone imbalance. Doctors order this test to investigate fatigue, obesity, high blood pressure, or irregular sleep patterns and to monitor adrenal disorders. It provides key insight into stress response and endocrine health.

The Cortisol Total Test measures cortisol levels in blood to assess adrenal gland and pituitary function. Cortisol regulates stress response, metabolism, and immune health. Abnormal results may indicate Cushing’s syndrome, Addison’s disease, or other hormone disorders. Doctors order this test to evaluate symptoms like fatigue, weight changes, weakness, or high blood pressure and to monitor treatment. It provides essential insight into hormone balance and endocrine health.

The Deoxycorticosterone Test evaluates adrenal gland function by measuring this mineralocorticoid precursor that influences salt retention and blood pressure. Abnormal levels may reflect congenital adrenal hyperplasia, adrenal tumors, or enzyme deficiencies impacting hormone synthesis. Results help providers investigate hypertension, electrolyte imbalance, and suspected adrenal endocrine disorders.

The Dexamethasone Suppression Test measures how cortisol levels respond after dexamethasone administration, assessing feedback within the hypothalamic-pituitary-adrenal (HPA) axis. Lack of suppression may indicate Cushing’s syndrome, pituitary adenoma, or adrenal disease. This test supports evaluation of metabolic disturbances such as obesity, hypertension, or glucose intolerance, offering valuable insight into endocrine balance and adrenal-pituitary function.

The DHEA Unconjugated Test measures levels of dehydroepiandrosterone, an adrenal hormone that serves as a precursor to testosterone and estrogen. Abnormal levels may indicate adrenal tumors, congenital adrenal hyperplasia, or hormone imbalance. Doctors order this test to evaluate infertility, irregular cycles, excess hair growth, or early puberty. Results provide insight into adrenal gland function, reproductive health, and endocrine disorders.