Bartonella Species Antibodies (IgG,IgM) W/Reflex

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The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Bartonella Species Antibodies IgGIgM WReflex Es To Titer

B. Henselae IgG Screen

B. Henselae IgM Screen

B. Quintana IgG Screen

B. Quintana IgM Screen

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The Bartonella Species Antibodies (IgG,IgM) W/Reflex test contains 1 test with 4 biomarkers.

Brief Description: The Bartonella Species IgG IgM Antibodies with Reflexes test is a comprehensive diagnostic tool used to detect the presence of IgG and IgM antibodies against various species of Bartonella bacteria in the blood. Bartonella infections are associated with a group of vector-borne diseases, and this test aids in diagnosing and monitoring these infections.

Additional charges my apply if one or more of the following reflex tests are run by the lab. If B. henselae (IgG) screen is positive, the B. henselae (IgG) titer will be performed at an additional charge (CPT code(s): 86611).
If B. quintana (IgG) screen is positive, the B. quintana (IgG) titer will be performed at an additional charge (CPT code(s): 86611).
If B. henselae (IgM) screen is positive, the B. henselae (IgM) titer will be performed at an additional charge (CPT code(s): 86611).
If B. quintana (IgM) screen is positive, the B. quintana (IgM) titer will be performed at an additional charge (CPT code(s): 86611).

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When and Why the Test is Ordered:

A healthcare provider may order the Bartonella Species IgG IgM Antibodies with Reflexes test when a patient exhibits symptoms suggestive of a Bartonella infection, such as fever, fatigue, muscle aches, and swollen lymph nodes. This test is particularly useful when other conditions with similar symptoms, such as Lyme disease, have been ruled out. It is also ordered when there is a suspicion of exposure to Bartonella through insect vectors like fleas, ticks, or lice.

What the Test Checks For:

The Bartonella Species IgG IgM Antibodies with Reflexes test evaluates the levels of both IgG and IgM antibodies specific to various Bartonella species. IgG antibodies are indicative of a past or ongoing infection, while IgM antibodies typically suggest a more recent infection.

Other Lab Tests and Their Purpose:

When a Bartonella Species IgG/IgM test is ordered, it's often part of a broader evaluation of a suspected Bartonella infection and its potential health impacts. Here are some tests commonly ordered alongside it:

  1. Complete Blood Count (CBC) with Differential:

    • Purpose: To evaluate overall blood health, including red and white blood cells, and platelets.
    • Why Is It Ordered: To check for signs of infection or anemia, which can occur with Bartonella infections.

  2. Blood Culture:

    • Purpose: To grow and identify bacteria from a blood sample.
    • Why Is It Ordered: To try to isolate and identify Bartonella species, although it's difficult to culture this bacterium in the laboratory.

  3. Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP):

    • Purpose: To measure markers of inflammation in the body.
    • Why Is It Ordered: To assess the level of systemic inflammation, which can be elevated in infectious diseases.

  4. Liver Function Test:

    • Purpose: To assess liver health.
    • Why Is It Ordered: To evaluate for liver involvement, as Bartonella can sometimes affect liver function.

These tests, when ordered alongside a Bartonella Species IgG/IgM Antibodies test, provide a comprehensive evaluation of a suspected Bartonella infection and help to assess its severity and potential complications. They are crucial for diagnosing Bartonella infection, ruling out or identifying co-infections, and guiding appropriate treatment. The specific combination of tests will depend on the individual’s symptoms, clinical presentation, and medical history.

Conditions Requiring the Test:

The Bartonella Species IgG IgM Antibodies with Reflexes test is ordered to diagnose and monitor various diseases caused by Bartonella species, including:

  • Cat Scratch Disease: Bartonella henselae, often transmitted through cat scratches or bites, is a common cause of this disease.

  • Trench Fever: Bartonella quintana, transmitted by body lice, can cause recurrent fever, fatigue, and muscle pain.

Utilization of Test Results:

The results of the Bartonella Species IgG IgM Antibodies with Reflexes test are used in several ways:

  • Diagnosis: Positive IgG or IgM antibody levels indicate exposure to Bartonella species and help confirm a diagnosis of Bartonella-related diseases.

  • Disease Monitoring: In cases of chronic Bartonella infections, regular testing and monitoring of antibody levels can provide insight into the effectiveness of treatment and disease progression.

  • Treatment Planning: Test results guide healthcare providers in tailoring appropriate antibiotic therapy for Bartonella infections.

  • Prevention and Education: Positive results may prompt healthcare providers to educate patients about the risks of exposure to Bartonella and preventive measures, especially for individuals with compromised immune systems.

  • Research: The data generated from this test contribute to research on Bartonella species, their prevalence, and the impact of these infections on public health.

In conclusion, the Bartonella Species IgG IgM Antibodies with Reflexes test is an essential tool for diagnosing and monitoring Bartonella infections. By detecting specific IgG and IgM antibodies against various Bartonella species, the test aids healthcare providers in confirming these infections and guiding appropriate treatment strategies. Test results support patient care, treatment planning, and ongoing research efforts related to Bartonella-related diseases.

Most Common Questions About the Bartonella Species IgG IgM Antibodies with Reflexes test:

Purpose and Applications

Why is the Bartonella Species IgG IgM Antibodies with Reflexes test ordered?

The Bartonella Species IgG IgM Antibodies with Reflexes test is primarily ordered to detect and diagnose an infection caused by the Bartonella species of bacteria. This group of bacteria can lead to several diseases in humans, such as cat-scratch disease, trench fever, and bacillary angiomatosis.

Who might need the Bartonella Species IgG IgM Antibodies with Reflexes test?

Individuals who present with symptoms consistent with Bartonella infections, such as fever, fatigue, swollen lymph nodes, and skin lesions, might be advised to undergo this test. Additionally, those who have been bitten or scratched by a potentially infected animal, especially cats, might also be recommended for testing.

Clinical Significance

What do positive results indicate in the Bartonella Species IgG IgM Antibodies with Reflexes test?

A positive result indicates the presence of antibodies against Bartonella species, suggesting a current or past infection. The presence of IgM antibodies typically indicates a recent infection, while IgG antibodies suggest a past infection.

Can the Bartonella Species IgG IgM Antibodies with Reflexes test differentiate between different Bartonella species?

The test primarily detects antibodies against Bartonella species as a group. Further tests, such as PCR or culture, may be required to identify the specific species or strain causing the infection.

Interpretation

If I've had a Bartonella infection in the past, will this test still show positive?

Yes, if you've had a Bartonella infection in the past, the test can show positive, especially for the IgG antibodies. These antibodies can remain in the system for a prolonged period after the infection has resolved.

How do healthcare providers differentiate between a current and past Bartonella infection using this test?

By evaluating the presence and levels of IgM and IgG antibodies, healthcare providers can differentiate between a current and past infection. Elevated IgM levels typically suggest a recent or current infection, while elevated IgG levels without elevated IgM levels indicate a past infection.

Clinical Limitations

Are there other conditions or factors that can influence the results of the Bartonella Species IgG IgM Antibodies with Reflexes test?

Yes, other infections or conditions might produce cross-reactive antibodies, leading to false-positive results. Additionally, early in the infection, antibodies might not be detectable, leading to false-negative results.

Additional Considerations

If my Bartonella Species IgG IgM Antibodies with Reflexes test is positive, what are the next steps?

A positive test suggests exposure to Bartonella species. If the test is positive and clinical symptoms are consistent with a Bartonella infection, your healthcare provider might initiate treatment. They might also order additional tests to confirm the diagnosis and rule out other conditions.

How can I prevent Bartonella infections in the future?

Prevention strategies include avoiding scratches and bites from cats, especially kittens, and using insect repellent to prevent bites from ticks and fleas, which can transmit the bacteria. Regularly checking pets for fleas and using flea control measures can also reduce the risk of Bartonella infections.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

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