Celiac Disease Nutrient Deficiency Panel

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Iron Total

Iron, Total

Iron is a mineral that our bodies need for many functions. For example, iron is part of hemoglobin, a protein which carries oxygen from our lungs throughout our bodies. It helps our muscles store and use oxygen. Iron is also part of many other proteins and enzymes. Your body needs the right amount of iron. If you have too little iron, you may develop iron deficiency anemia. Causes of low iron levels include blood loss, poor diet, or an inability to absorb enough iron from foods. People at higher risk of having too little iron are young children and women who are pregnant or have periods.

Vitamin D, 25-Oh, D2

Vitamin D2 ((ergocalciferol,) is found in fortified foods and in most vitamin preparations and supplements. Vitamin D comes from two sources: endogenous, which is produced in the skin on exposure to sunlight, and exogenous, which is ingested in foods and supplements. The D2 form is found in fortified foods and in most vitamin preparations and supplements. Vitamin D2 is effective when it is converted by the liver and the kidney into the active form, 1,25-dihydroxyvitamin D.

Vitamin D, 25-Oh, D3

Vitamin D3 (cholecalcifero) which comes from animals. Vitamin D comes from two sources: endogenous, which is produced in the skin on exposure to sunlight, and exogenous, which is ingested in foods and supplements. Vitamin D3 is the form produced in the body and is also used in some supplements. Vitamin D3 are is converted by the liver and the kidney into the active form, 1,25-dihydroxyvitamin D.

Vitamin D, 25-Oh, Total

Vitamin D comes from two sources: endogenous, which is produced in the skin on exposure to sunlight, and exogenous, which is ingested in foods and supplements. The chemical structures of the types of vitamin D are slightly different, and they are named vitamin D2 (ergocalciferol, which comes from plants) and vitamin D3 (cholecalciferol, which comes from animals). The D2 form is found in fortified foods and in most vitamin preparations and supplements. Vitamin D3 is the form produced in the body and is also used in some supplements. Vitamin D2 and D3 are equally effective when they are converted by the liver and the kidney into the active form, 1,25-dihydroxyvitamin D.

Vitamin D, 25-Oh, Total

Vitamin D comes from two sources: endogenous, which is produced in the skin on exposure to sunlight, and exogenous, which is ingested in foods and supplements. The chemical structures of the types of vitamin D are slightly different, and they are named vitamin D2 (ergocalciferol, which comes from plants) and vitamin D3 (cholecalciferol, which comes from animals). The D2 form is found in fortified foods and in most vitamin preparations and supplements. Vitamin D3 is the form produced in the body and is also used in some supplements. Vitamin D2 and D3 are equally effective when they are converted by the liver and the kidney into the active form, 1,25-dihydroxyvitamin D.

Also known as: Retinol, Vitamin A, Vitamin A Retinol

Vitamin A

This test measures the level of retinol in the blood; retinol is the primary form of vitamin A in animals. Vitamin A is an essential nutrient required for healthy vision, skin growth and integrity, bone formation, immune function, and embryonic development. It is required to produce photoreceptors in the eyes and to maintain the lining of the surface of the eyes and other mucous membranes. Deficiencies in vitamin A can impair night vision, cause eye damage, and in severe cases lead to blindness. Acute or chronic excesses of vitamin A can be toxic, cause a range of symptoms, and sometimes lead to birth defects. The body cannot make vitamin A and must rely on dietary sources of vitamin A. Meat sources provide vitamin A (as retinol), while vegetable and fruit sources provide carotene (a substance that can be converted into vitamin A by the liver). Vitamin A is stored in the liver and fat tissues (it is fat-soluble), and healthy adults may have as much as a year's worth stored. The body maintains a relatively stable concentration in the blood through a feedback system that releases vitamin A from storage as needed and increases or decreases the efficiency of dietary vitamin A absorption.

Also known as: B1, B1 Vitamin, Thiamine, Vitamin B1, Vitamin B1 Thiamine LCMSMS

Vitamin B1 (Thiamine),

Also known as: Cobalamin, Folic Acid, Vitamin B 12, Vitamin B 12 and Folic Acid, Vitamin B12 Cobalamin and Folate Panel Serum, Vitamin B12/Folic Acid

Folate, Serum

Folate is part of the B complex of vitamins and is measures the levels of folate in the liquid portion of the blood, the serum or plasma, to detect deficiencies. Folate is necessary for normal RBC formation, tissue and cellular repair, and DNA synthesis.. A deficiency inr folate can lead to macrocytic anemia. Megaloblastic anemia, a type of macrocytic anemia, is characterized by the production of fewer but larger RBCs called macrocytes, in addition to some cellular changes in the bone marrow.

Vitamin B12

Vitamin B12 is part of the B complex of vitamins and measurea the levels of vitamin B12 in the liquid portion of the blood, the serum or plasma, to detect deficiencies. Cobalamine, or vitamin B12, is found in animal products such as red meat, fish, poultry, milk, yogurt, and eggs and is not produced in the human body. In recent years, fortified cereals, breads, and other grain products have also become important dietary sources of B12. Vitamin B12 is necessary for normal RBC formation, tissue and cellular repair, and DNA synthesis. B12 is important for nerve health. A deficiency in B12 can lead to macrocytic anemia. Megaloblastic anemia, a type of macrocytic anemia, is characterized by the production of fewer but larger RBCs called macrocytes, in addition to some cellular changes in the bone marrow. B12 deficiency can lead to varying degrees of neuropathy, nerve damage that can cause tingling and numbness in the affected person's hands and feet.

Also known as: B6, B6 Vitamin, Pyridoxal, Pyridoxal Phosphate, Pyridoxal Phosphate (PLP), Vitamin B6 Pyridoxal Phosphate

Factor X Activity,

Vitamin B6

Also known as: Alpha-Tocopherol, Vitamin E Tocopherol

Alpha-Tocopherol

Beta-Gamma-Tocopherol

Vitamin K

Vitamin K helps your body by making proteins for healthy bones and tissues. It also makes proteins for blood clotting. If you don't have enough vitamin K, you may bleed too much.
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The Celiac Disease Nutrient Deficiency Panel panel contains 8 tests with 14 biomarkers.

The Celiac Disease Nutrient Deficiency Panel is a comprehensive diagnostic tool designed to assess levels of essential vitamins and minerals that are often deficient in individuals with celiac disease. Celiac disease is an autoimmune disorder where the ingestion of gluten leads to damage in the small intestine, impairing nutrient absorption. This panel evaluates multiple vitamins and minerals to identify deficiencies that can contribute to various health issues, enabling healthcare providers to develop effective treatment plans.

When and Why the Celiac Disease Nutrient Deficiency Panel May Be Ordered

This panel may be ordered for patients diagnosed with celiac disease or those exhibiting symptoms suggestive of the condition, such as chronic diarrhea, weight loss, fatigue, and malnutrition. It is particularly useful for monitoring nutritional status after a diagnosis of celiac disease, during follow-up visits, or when symptoms persist despite a gluten-free diet. The panel can also be beneficial for individuals with other malabsorption syndromes or gastrointestinal disorders that may lead to nutrient deficiencies.

What the Celiac Disease Nutrient Deficiency Panel Checks For

The Celiac Disease Nutrient Deficiency Panel includes several key tests to measure levels of essential nutrients:

  • Vitamin A: Vitamin A is crucial for vision, immune function, and skin health. Deficiency can lead to night blindness and increased susceptibility to infections.
  • Vitamin B1 (Thiamine): Thiamine is vital for energy metabolism and neurological function. Deficiency can cause beriberi and neurological symptoms like confusion and muscle weakness.
  • Vitamin B6 (Pyridoxine): Pyridoxine is essential for amino acid metabolism and neurotransmitter synthesis. Deficiency can result in anemia, dermatitis, and neuropathy.
  • Vitamin B9 (Folate): Folate is crucial for DNA synthesis and repair, as well as red blood cell production. Deficiency is linked to anemia and neural tube defects in pregnancy.
  • Vitamin B12 (Cobalamin): Cobalamin is critical for neurological function and red blood cell formation. Deficiency can lead to megaloblastic anemia and neurological issues.
  • Vitamin D: Vitamin D is essential for calcium absorption and bone health. Deficiency can lead to rickets in children and osteomalacia in adults.
  • Vitamin E: An antioxidant that protects cells from oxidative stress. Deficiency may contribute to neurodegeneration and muscle weakness.
  • Vitamin K: Vitamin K is necessary for blood clotting and bone metabolism. Deficiency can result in bleeding disorders and reduced bone density.
  • Iron: Iron is crucial for the production of hemoglobin, which carries oxygen in the blood. Deficiency can lead to iron deficiency anemia, characterized by fatigue and weakness.

Conditions or Diseases the Celiac Disease Nutrient Deficiency Panel Can Detect

The Celiac Disease Nutrient Deficiency Panel can help detect several conditions associated with nutrient deficiencies:

  • Celiac Disease: An autoimmune disorder where ingestion of gluten leads to damage in the small intestine, causing malabsorption of nutrients. The panel can detect deficiencies in vitamins and minerals that result from this malabsorption, allowing for targeted nutritional interventions.
  • Malabsorption Syndromes: Conditions where the small intestine cannot absorb nutrients effectively, leading to deficiencies. The panel helps identify specific nutrient deficiencies, guiding appropriate supplementation and dietary modifications.
  • Anemia: Various forms of anemia, including iron deficiency anemia and megaloblastic anemia, can be detected through this panel. It identifies deficiencies in iron, folate, and vitamin B12, which are critical for red blood cell production.

How a Healthcare Professional Would Use the Results of the Celiac Disease Nutrient Deficiency Panel

Healthcare professionals use the results of the Celiac Disease Nutrient Deficiency Panel to:

  • Diagnose and Manage Celiac Disease: Identifying nutrient deficiencies allows for targeted supplementation and dietary adjustments to correct deficiencies and improve overall health. Regular monitoring helps ensure ongoing nutritional adequacy.
  • Address Malabsorption Syndromes: By detecting specific nutrient deficiencies, healthcare providers can tailor treatment plans to address the root cause of malabsorption and improve nutrient absorption through dietary changes and supplements.
  • Treat Anemia: If deficiencies in iron, folate, or vitamin B12 are detected, healthcare providers can prescribe appropriate supplements and recommend dietary changes to increase the intake of these nutrients, thereby treating and preventing anemia.

Conclusion

The Celiac Disease Nutrient Deficiency Panel is an essential diagnostic tool for identifying and managing nutrient deficiencies in individuals with celiac disease and other malabsorption disorders. By assessing levels of key vitamins and minerals, this panel provides valuable insights that enable healthcare providers to develop personalized treatment plans, improve nutritional status, and enhance overall health and well-being. Whether for diagnosing conditions like anemia or addressing nutrient deficiencies due to malabsorption, this panel supports comprehensive patient care and effective disease management.

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