Comprehensive Autoimmune Disorder Diagnostic Panel

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: ANA, ANA Screen IFA with Reflex to Titer and Pattern IFA, ANA with Reflux

ANA Screen, IFA

The antinuclear antibody (ANA) test is ordered to help screen for autoimmune disorders and is most often used as one of the tests to diagnose systemic lupus erythematosus (SLE).

Also known as: C-Reactive Protein, CReactive Protein CRP, CRP

C-REACTIVE PROTEIN

C-reactive protein is produced by the liver. The level of CRP rises when there is inflammation throughout the body.

Complement Component C3c

Complement Component C4c

Also known as: ACPA, Anti-CCP, Anti-citrulline Antibody, Anti-cyclic Citrullinated Peptide, Anti-Cyclic Citrullinated Peptide (CCP) Antibody IgG, CCP, CCP Antibody, Citrullinated Peptide (CCP) IgG, Cyclic Citrullinated Peptide Antibody, Cyclic Citrullinated Peptide CCP Antibody IgG

Cyclic Citrullinated

Also known as: (dsDNA), Anti-DNA, DNA ds Antibody, Double-Stranded DNA Antibody, dsDNA, Native DNA

Dna (Ds) Antibody

Also known as: RF

Rheumatoid Factor

Rheumatoid factor (RF) is a blood test that measures the amount of the RF antibody in the blood. An abnormal result means the test is positive, which means higher levels of rheumatoid factor have been detected in your blood. Most patients with rheumatoid arthritis or Sjogren syndrome have positive RF tests. The higher the level, the more likely one of these conditions is present. Not everyone with higher levels of rheumatoid factor has rheumatoid arthritis or Sjogren syndrome.

Also known as: ESR, SED RATE, Sed Rate by Modified Westergren ESR

Sed Rate By Modified

Erythrocyte sedimentation rate (ESR) is an indirect measure of the degree of inflammation present in the body. It actually measures the rate of fall (sedimentation) of erythrocytes (red blood cells) in a sample of blood.
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The Comprehensive Autoimmune Disorder Diagnostic Panel panel contains 8 tests with 8 biomarkers.

The Comprehensive Autoimmune Disorder Diagnostic Panel is meticulously designed to evaluate and diagnose various autoimmune conditions through a series of targeted tests, each contributing unique and crucial data:

  1. ANA Screen, IFA with Reflex to Titer and Pattern, IFA: This test detects antinuclear antibodies (ANA) which are commonly present in various autoimmune disorders. A positive ANA test may lead to further testing with a titer and pattern via Immunofluorescence Assay (IFA) to determine the concentration of antibodies and the specific staining pattern, helping to pinpoint specific autoimmune diseases.

  2. C-Reactive Protein (CRP): CRP levels increase in response to inflammation. Measuring CRP is valuable for assessing the severity and flare-ups of inflammatory autoimmune disorders such as rheumatoid arthritis and lupus.

  3. Complement Component C3c and C4c: These tests measure the levels of complement proteins, which play essential roles in the immune system. Low levels of C3c and C4c are often associated with systemic lupus erythematosus (SLE) and other immune complex diseases, reflecting the degree of active immune response.

  4. Cyclic Citrullinated Peptide (CCP) Antibody (IgG): This test is highly specific for rheumatoid arthritis (RA). The presence of CCP antibodies often indicates RA even before symptoms become apparent, making it a critical marker for early diagnosis.

  5. DNA (ds) Antibody: This test detects antibodies against double-stranded DNA, which are primarily associated with SLE. High levels typically indicate active disease and are used to monitor disease activity and severity.

  6. Rheumatoid Factor (RF): RF is an antibody found in approximately 80% of people with rheumatoid arthritis but can also be present in other autoimmune diseases. This test helps in diagnosing RA and can also be indicative of Sjögren's syndrome, lupus, and other autoimmune conditions.

  7. Sed Rate by Modified Westergren (ESR): Erythrocyte sedimentation rate (ESR) is a non-specific test used to detect inflammation associated with conditions like autoimmune disease. An elevated ESR can indicate active inflammation but must be interpreted alongside other clinical findings.

Together, these tests provide a comprehensive assessment, aiding in the diagnosis and management of autoimmune diseases by identifying specific antibodies, evaluating inflammatory activity, and monitoring disease progression.

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