Cytochrome P450 2D6 Genotype

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The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Cytochrome P450 2d6

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The Cytochrome P450 2D6 Genotype test contains 1 test with 1 biomarker.

Clinical Significance

Cytochrome P450 2D6 Genotype - The CYP2D6 gene product is responsible for the metabolism of many major drug groups including many antidepressants, neuroleptics, and cardiovascular drugs. Cytochrome 450 2D6 Genotype detects eight alleles associated with the poor metabolizer phenotype (PM). Patients with duplication of the CYP2D6 gene are ultraextensive metabolizers (UEM). Approximately 5-10% of Caucasian individuals express PM phenotype and the same percentage the UEM phenotype.

Alternative Name(s)

2D6,Tamoxifen Resistance,CYP2D6

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