The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.
Also known as: Factor Ix Activity Clotting
The Factor IX Activity, Clotting test contains 1 test with 1 biomarker.
Clinical Significance
Factor IX Activity, Clotting - This test is useful to evaluate a prolonged aPTT. Deficiency of Factor IX can be seen with congenital deficiency (Hemophilia B, X-linked disorder) which affects approximately 1 in 25,000 males. As a vitamin K-dependent clotting factor, decreased levels are also observed with vitamin K antagonists (eg. warfarin therapy) and vitamin K deficiency. Deficiencies may be seen with liver disease, disseminated intravascular coagulation (DIC) and in other consumptive coagulopathies.
Anticoagulant interference: Expected impact by therapeutic levels (potential interference depends upon drug concentration): Warfarin: decrease; Heparin (UFH or LMWH): no effect to inhibitor pattern; Dabigatran or Argatroban (Thrombin Inhibitors): no effect to inhibitor pattern; Rivaroxaban, Apixaban, Edoxaban (Factor Xa Inhibitors): no effect to inhibitor pattern. Other limitations: Lupus anticoagulant may cause falsely low to inhibitor pattern. Factor specific inhibitors (autoantibodies or in response to replacement therapies) may cause falsely low or inhibitor patterns.