Gluten Sensitivity and Celiac Diagnostic Panel with HLA Typing

The Gluten Sensitivity and Celiac Diagnostic Panel with HLA Typing panel contains 7 tests with 14 biomarkers.

The Gluten Sensitivity and Celiac Diagnostic Panel with HLA Typing is an extensive testing suite designed to accurately diagnose gluten sensitivity, wheat allergy, and celiac disease.

Each test in this panel serves a specific function in identifying the presence and type of immune response to gluten and determining the genetic predisposition to celiac disease.

Here's how each test can benefit a person:

1. Gluten (f79) IgE

   • Purpose: This test measures IgE antibodies specific to gluten proteins. It helps identify immediate allergic reactions to gluten, which can manifest as skin, respiratory, or gastrointestinal symptoms shortly after gluten consumption.
   • Benefit: Enables individuals to understand if their symptoms are related to a true gluten allergy, guiding dietary adjustments and allergen management strategies.

2. IgE

   • Purpose: This general test measures the level of IgE antibodies in the blood, which are elevated in various allergic conditions.
   • Benefit: Provides a baseline understanding of an individual's allergic status, which can help in assessing the severity and scope of allergic responses.

3. Tissue Transglutaminase (tTG) Antibodies (IgG, IgA)

   • Purpose: These tests check for antibodies against tissue transglutaminase, a key enzyme involved in the reaction that leads to intestinal damage in celiac disease.
   • Benefit: Crucial for diagnosing celiac disease, as positive results are highly indicative of this autoimmune disorder. Helps differentiate between celiac disease and non-celiac gluten sensitivity.

4. Endomysial Antibody Scr (IgA) W/Refl To Titer

   • Purpose: This test detects antibodies against the endomysium, part of the connective tissue around muscle fibers, often damaged in celiac disease.
   • Benefit: Highly specific for celiac disease, providing confirmation of the diagnosis, particularly when tTG tests are positive.

5. Gliadin (Deamidated Peptide) Antibody (IgG, IgA)

   • Purpose: Measures antibodies to deamidated forms of gliadin, a component of gluten. These modified peptides form during digestion and trigger immune responses in celiac disease.
   • Benefit: Helps in diagnosing both classic celiac disease and its subtler forms, useful in patients with ambiguous symptoms or who have already started a gluten-free diet.

6. Immunoglobulin A (IgA)

   • Purpose: Measures the total level of IgA in the blood, an important part of the body’s immune system.
   • Benefit: Essential for validating the accuracy of other IgA-based celiac tests. IgA deficiency can lead to false negatives, so knowing IgA status ensures more accurate diagnostic results.

7. HLA Typing for Celiac Disease

   • Purpose: Genetic test that checks for HLA-DQ2 and HLA-DQ8 haplotypes, which are necessary but not solely sufficient for the development of celiac disease.
   • Benefit: A negative result almost entirely rules out celiac disease, reducing unnecessary long-term dietary restrictions and further invasive testing.

The Gluten Sensitivity and Celiac Diagnostic Panel with HLA Typing is a comprehensive tool for anyone experiencing symptoms related to gluten ingestion.

It not only facilitates the accurate diagnosis of related conditions but also informs better health management decisions.

Utilizing this panel, individuals can receive targeted treatment and dietary recommendations that significantly improve their quality of life.