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The Gonadotropin Releasing Hormone test contains 1 test with 1 biomarker.
Gonadotropin Releasing Hormone - Gonadotropin releasing hormone (Gn RH or LH RH) is a ten amino acid peptide produced mainly in the hypothalamus. It stimulates pituitary for the production of LH and FSH.
The stimulation is predominantly on LH secretion and hence it is called LH RH. LH and FSH stimulate the production of gonadal hormones (e.g testosterone in males and estrogens in females). These steroid hormones have a feedback control on Gn RH secretion. Increased secretion occurs during puberty leading to the raise in concentration of LH and FSH for the stimulation of gonads. LH RH levels are high when there is secondary hypogonadism with decreased level of LH and FSH. LH RH levels are low in tertiary (hypothalamic) hypogonadism and also individuals with high stress levels with elevated dopamine and prolactin. LH RH and its agonists are routinely used in IVF settings to induce ovulation.
Preferred Specimen(s)
3 mL frozen plasma collected in an EDTA (lavender-top) tube
Collection Instructions
Centrifuge and transfer 3 mL plasma into a transfer tube. Ship frozen.