Healthy Blood Vessels - The Advanced Lipid Panel with Lp(a)

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Apolipoprotein B

Also known as: Lipid Panel with Ratios (fasting), Lipid Profile with Ratios (fasting), Lipids

Chol/HDLC Ratio

Cholesterol, Total

Cholesterol is a waxy, fat-like substance that occurs naturally in all parts of the body. Your body needs some cholesterol to work properly. But if you have too much in your blood, it can combine with other substances in the blood and stick to the walls of your arteries. This is called plaque. Plaque can narrow your arteries or even block them. High levels of cholesterol in the blood can increase your risk of heart disease. Your cholesterol levels tend to rise as you get older. There are usually no signs or symptoms that you have high blood cholesterol, but it can be detected with a blood test. You are likely to have high cholesterol if members of your family have it, if you are overweight or if you eat a lot of fatty foods. You can lower your cholesterol by exercising more and eating more fruits and vegetables. You also may need to take medicine to lower your cholesterol.

HDL Cholesterol

LDL-Cholesterol

LDL/HDL Ratio

Non HDL Cholesterol

Triglycerides

Triglycerides are a form of fat and a major source of energy for the body. This test measures the amount of triglycerides in the blood. Most triglycerides are found in fat (adipose) tissue, but some triglycerides circulate in the blood to provide fuel for muscles to work. After a person eats, an increased level of triglycerides is found in the blood as the body converts the energy not needed right away into fat. Triglycerides move via the blood from the gut to adipose tissue for storage. In between meals, triglycerides are released from fat tissue to be used as an energy source for the body. Most triglycerides are carried in the blood by lipoproteins called very low density lipoproteins (VLDL). High levels of triglycerides in the blood are associated with an increased risk of developing cardiovascular disease (CVD), although the reason for this is not well understood. Certain factors can contribute to high triglyceride levels and to risk of CVD, including lack of exercise, being overweight, smoking cigarettes, consuming excess alcohol, and medical conditions such as diabetes and kidney disease.

Also known as: Lipoprotein A, Lp (a), Lp(a)

Lipoprotein (A)

Lipoprotein-a, or Lp(a) are molecules made of proteins and fat. They carry cholesterol and similar substances through the blood. A high level of Lp(a) is considered a risk factor for heart disease. High levels of lipoproteins can increase the risk of heart disease. The test is done to check your risk of atherosclerosis, stroke, and heart attack.

Also known as: Ion Mobility, Cardio IQ Lipoprotein Fractionation, Ion Mobility , HDL Subfractions, IDL Subfractions, LDL Subfractions, Lipoprotein Fraction, Lipoprotein Fractionation, Lipoprotein Fractionation Ion Mobility Cardio IQ, Quest Diagnostics has replaced the VAP® Cholesterol Test with Lipoprotein Fractionation, Ion Mobility, Cardio IQ™ test

HDL Large

LDL Medium

LDL Particle Number

LDL Pattern

LDL Peak Size

LDL Small

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The Healthy Blood Vessels - The Advanced Lipid Panel with Lp(a) panel contains 4 tests with 15 biomarkers.

Brief Description: The Healthy Blood Vessels - The Advanced Lipid Panel with Lp(a) is a comprehensive diagnostic tool designed to provide an in-depth assessment of cardiovascular risk based on lipid profile and specific markers associated with cardiovascular diseases. This panel includes tests for Apolipoprotein B, Lipoprotein (a), a traditional Lipid Panel with Ratios, and Lipoprotein Fractionation Ion Mobility. By evaluating these specific biomarkers, the panel offers a nuanced view of lipid metabolism and its implications for heart health, beyond what a standard lipid panel provides.

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: Fasting for 12 hours is required.

When and Why the Panel May Be Ordered

This panel may be ordered for individuals with a family history of heart disease, those with existing cardiovascular conditions, or when traditional lipid panels suggest elevated risk. It's also recommended for those with risk factors such as hypertension, diabetes, smoking, obesity, or a sedentary lifestyle. The advanced insights provided by this panel assist in refining risk assessment and tailoring more effective prevention and treatment strategies for cardiovascular diseases.

What the Panel Checks For: Description of Tests Within Panel

Apolipoprotein B (ApoB)

ApoB is the primary protein component of LDL cholesterol and VLDL particles. High levels of ApoB indicate a greater number of atherogenic particles, contributing to plaque buildup in arteries.

Lipoprotein (a) (Lp(a))

Lp(a) is a variant of LDL cholesterol with an additional protein that makes it more likely to cause inflammation and clotting. Elevated Lp(a) levels are considered a significant risk factor for cardiovascular diseases.

Lipid Panel with Ratios

This test measures total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides, providing ratios of these lipids that help assess cardiovascular risk.

Lipoprotein Fractionation Ion Mobility

This advanced technique separates lipoproteins by size and density, offering detailed information on the distribution of lipid particles, including small, dense LDL particles that are more atherogenic.

Conditions and Diseases the Panel Can Detect

Cardiovascular Disease

The panel's comprehensive assessment identifies individuals at increased risk for coronary artery disease, stroke, and peripheral artery disease by highlighting elevated levels of atherogenic lipoproteins.

Atherosclerosis

By detecting elevated levels of ApoB, Lp(a), and small, dense LDL particles, the panel can identify individuals at risk for atherosclerosis, characterized by plaque buildup in the arteries.

How a Provider Uses the Results of the Panel to Monitor or Treat the Diseases and Conditions It Can Detect

Cardiovascular Disease

Providers can use the detailed information from the panel to personalize treatment plans, including lifestyle changes, statin therapy, and other medications to manage lipid levels and reduce cardiovascular risk.

Atherosclerosis

The detection of specific lipid abnormalities enables targeted interventions to slow plaque buildup, such as dietary modifications, increased physical activity, and possibly the use of niacin or fibrates to improve lipid particle profiles.

The Healthy Blood Vessels - The Advanced Lipid Panel with Lp(a) offers a sophisticated evaluation of cardiovascular risk, providing valuable insights that go beyond traditional lipid measurements. By identifying key risk factors for cardiovascular disease and atherosclerosis, this panel enables healthcare professionals to implement precise and effective strategies for prevention, monitoring, and treatment. Utilizing this advanced panel supports a proactive approach to cardiovascular health, aiming to mitigate risk and improve long-term outcomes for individuals at risk of heart disease.

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