Mutated Citrullinated Vimentin (MCV) Antibody

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The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

MUTATED CITRULLINATED VIMENTIN (MCV) AB

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The Mutated Citrullinated Vimentin (MCV) Antibody test contains 1 test with 1 biomarker.

Test Description for Mutated Citrullinated Vimentin (MCV) Antibody:

Name: Mutated Citrullinated Vimentin (MCV) Antibody Test

Also Known as: anti-MCV,RA,Rheumatoid arthritis

Purpose: The Mutated Citrullinated Vimentin (MCV) Antibody test is utilized as a secondary marker in the diagnosis of rheumatoid arthritis (RA). It serves to complement primary markers like rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibodies.

Test Significance: Anti-MCV antibodies are part of a group of anti-citrullinated protein antibodies (ACPAs) that target mutated citrullinated vimentin. While the MCV antibody test is slightly less specific than the anti-CCP test, it offers marginally higher sensitivity. Including an MCV antibody test alongside the CCP test can enhance the sensitivity of RA diagnosis by an additional 5-10%.

Clinical Relevance: The presence of MCV antibodies is not only indicative of RA but is also correlated with a more aggressive disease course. Patients who test positive for MCV antibodies often exhibit more severe RA symptoms and show greater radiological progression over time.

Testing Methodology: The detection of MCV antibodies is typically conducted via immunoassays that quantify the level of these antibodies in the patient's blood.

Interpretation: Positive results for MCV antibodies may necessitate further investigation and can be a significant factor in the management and treatment planning of rheumatoid arthritis, due to its association with more severe disease prognosis.

Reference Range(s)
<20 U/mL

Note: The test is most effective when used in conjunction with other RA markers, and results should be evaluated by a healthcare professional within the broader context of clinical findings and patient history.

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