The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.
The Phosphatidylserine/Prothrombin (PS/PT) Antibody (IgG) test contains 1 test with 1 biomarker.
Phosphatidylserine/Prothrombin (PS/PT) Antibody (IgG)
Clinical Significance
Phosphatidylserine/Prothrombin (PS/PT) Antibody (IgG) - Antiphospholipid Syndrome (APS) is an acquired autoimmune thrombophilia characterized by thrombosis (venous and/or arterial or microvascular) and/or pregnancy loss or morbidity in association with persistent positivity of a heterogenous group of autoantibodies known as anti- phospholipid antibodies (APL).
The international laboratory consensus criteria for the diagnosis of APS includes a positive lupus anticoagulant and/or moderate to high positivity for IgG/IgM Cardiolipin and Beta-2-Glycoprotein I antibodies. Although not included in the criteria classification for APS diagnosis, antibodies directed against a phosphatidylserine/prothrombin complex (PS/PT) have been reported to have a high association with venous thrombosis and obstetric abnormalities, but not with arterial thrombosis. In addition, a very high degree of concordance between the concentration of aPS/PT and lupus anticoagulant activity has been demonstrated.
Reference Range(s)
≤30 U
Alternative Name(s)
PSPT IgG Antibodies,aPS/PT IgG