Ulta Lab Tests

Quest AD-Detect Phosphorylated tau181 (p-tau181)

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The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

QUEST AD DETECT PTAU181,

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The Quest AD-Detect Phosphorylated tau181 (p-tau181) test contains 1 test with 1 biomarker .

The Quest AD-Detect Phosphorylated tau181 (p-tau181) test in plasma is a specialized assay used to aid in the diagnosis of Alzheimer's Disease (AD). By measuring levels of phosphorylated tau protein 181 (p-tau181), a key biomarker, this test provides critical insights into the presence of AD tau pathology, which is indicative of Alzheimer’s Disease.

Clinical Significance: The presence of p-tau181 in plasma is a significant indicator of Alzheimer's Disease, helping to identify patients exhibiting underlying AD tau pathology. This biomarker is effective in predicting cognitive decline in patients with Alzheimer's or Mild Cognitive Impairment (MCI) and shows a correlation with amyloid and tau PET imaging results.

Preferred Specimen(s):

  • 1 mL of plasma collected in an EDTA (lavender-top) tube.

Test Summary: Quest AD-Detect Phosphorylated tau181 (p-tau181) is conducted on a plasma sample to aid in the early detection and management of Alzheimer’s Disease.

Patient Preparation:

  • Avoid dietary supplements containing biotin as they may interfere with the test results. Biotin should be discontinued for at least 8 hours before testing if taken in normal doses, and at least 72 hours before testing if taken in mega-doses.

Methodology:

  • The test uses Electrochemiluminescence (ECLIA) for detecting and quantifying p-tau181 in plasma.

Assay Category:

  • This test was developed and its performance characteristics determined by Quest Diagnostics. It is not FDA-approved but is validated under CLIA regulations for clinical use.

Reference Range(s):

  • Individuals younger than 55 years: ≤0.86 pg/mL
  • Individuals 55 years and older: ≤1.07 pg/mL

Alternative Name(s):

  • PhosphoTau-181P

Utilizing the Quest AD-Detect Phosphorylated tau181 (p-tau181) test, healthcare providers can obtain vital diagnostic information regarding Alzheimer's Disease, facilitating earlier and more targeted interventions based on a patient’s specific tau pathology. This can significantly aid in planning appropriate treatments and managing the progression of the disease.

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