Ulcerative Colitis Differentiation Panel

The Ulcerative Colitis Differentiation Panel test contains 1 test with 5 biomarkers.

Test Description: Ulcerative Colitis Differentiation Panel

Purpose: The Ulcerative Colitis Differentiation Panel is a specialized serological test panel designed to assist in the diagnosis and differentiation of Ulcerative Colitis (UC), a subtype of Inflammatory Bowel Disease (IBD). By measuring specific antibodies commonly associated with UC, this panel helps clinicians distinguish UC from Crohn’s Disease (CD) and other gastrointestinal conditions.

Important Notice: Please be advised that this panel includes tests that may trigger reflexive testing. By ordering this panel, you acknowledge and consent to be charged for any additional tests that may be conducted based on reflex criteria, as detailed in the aforementioned fee schedule.

Components:

1. ANCA Screen with Reflex to ANCA Titer:

   • This test screens for the presence of anti-neutrophil cytoplasmic antibodies (ANCA), which are associated with various autoimmune conditions, including certain types of vasculitis and IBD. If the ANCA screen is positive, additional reflex testing to determine the specific ANCA titer (C-ANCA, P-ANCA, or atypical P-ANCA) will be automatically performed at an additional charge, providing a detailed analysis to aid in diagnosis.

2. Myeloperoxidase Antibody (MPO):

   • MPO antibodies are part of the ANCA profile and are commonly associated with P-ANCA. Their presence can indicate certain autoimmune conditions and vasculitides.

3. Proteinase-3 Antibody:

   • Proteinase-3 antibodies are typically associated with C-ANCA and can be found in patients with Wegener’s Granulomatosis, a form of vasculitis.

4. Saccharomyces cerevisiae Antibodies (ASCA) (IgG):

   • ASCA IgG antibodies are more commonly associated with Crohn’s Disease, but their presence or absence can also provide valuable information in the context of differentiating UC.

5. Saccharomyces cerevisiae Antibodies (ASCA) (IgA):

   • Like ASCA IgG, ASCA IgA antibodies are used in the differentiation of IBD subtypes, aiding in the diagnostic process.

Reflex Testing:

• If the ANCA screen is positive, reflex testing to ANCA titer will be performed at an additional charge (CPT code(s): 86037 for each titer performed). This reflex testing allows for a comprehensive evaluation and detailed characterization of the type of ANCA antibodies present.

Interpretation:

• A positive P-ANCA result, in conjunction with other clinical findings, is commonly associated with Ulcerative Colitis.
• ASCA antibodies are more commonly associated with Crohn’s Disease; however, their presence or absence, along with ANCA results, can provide valuable information in differentiating UC from CD and other gastrointestinal conditions.
• Results should be interpreted in the context of the patient’s clinical presentation, other laboratory tests, and imaging studies.

Utility:

• This panel provides a targeted approach for the diagnosis and differentiation of Ulcerative Colitis, aiding clinicians in making timely and accurate decisions regarding patient management and treatment.
• It is particularly valuable in complex cases where the clinical presentation may be ambiguous, and additional laboratory data is required for a comprehensive evaluation.

Limitations:

• The presence of these antibodies alone is not diagnostic of Ulcerative Colitis or any specific subtype of IBD.
• Seronegative cases of UC are possible, and a negative result does not rule out the disease.
• Additional clinical correlation and further diagnostic evaluation are required for a definitive diagnosis.

The Ulcerative Colitis Differentiation Panel is an essential tool in the diagnostic arsenal for IBD, providing clarity and aiding clinicians in the complex process of diagnosing and managing Ulcerative Colitis.

Methodology

Immunoassay (IA)

Reference Range(s)

Myeloperoxidase Antibody

Proteinase-3 Antibody

Saccharomyces cerevisiae Ab (IgG)

Saccharomyces cerevisiae Ab (IgA)