Iron Excessive (Hemochromatosis)

Iron Excessive (Hemochromatosis)—often called iron overload—happens when the body absorbs or retains too much iron. Extra iron is stored in organs like the liver, heart, and pancreas, where it can cause inflammation and long-term damage. Causes include hereditary hemochromatosis (HFE gene variants such as C282Y/H63D) and secondary iron overload from repeated transfusions or certain blood/ liver conditions.

Because early symptoms are subtle—fatigue, joint pain, or abnormal liver tests—lab testing is essential for screening, confirming iron overload, and monitoring trends over time. Ulta Lab ... See more

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The Hereditary Hemochromatosis DNA Mutation Analysis evaluates mutations in the HFE gene that contribute to hereditary iron overload. Abnormal results may explain unexplained fatigue, liver dysfunction, joint issues, or heart disease. This test supports assessment of genetic predisposition, metabolic balance, and systemic conditions caused by excess iron accumulation and hemochromatosis-related complications.

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The Transferrin Test measures transferrin, a blood protein that transports iron, to evaluate iron status and nutritional health. High levels may suggest iron deficiency anemia, while low levels may indicate liver disease, malnutrition, or chronic illness. Doctors use this test alongside iron and TIBC to investigate fatigue, weakness, or anemia symptoms. Results provide vital insight into iron balance, red blood cell production, and overall metabolic function.

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The Ferritin Test measures ferritin, a protein that stores iron in the body, to evaluate iron levels and detect deficiency or overload. It helps diagnose anemia, iron deficiency, hemochromatosis, and chronic disease-related inflammation. Doctors often order the ferritin test to investigate fatigue, weakness, or unexplained symptoms. It is also used to monitor iron supplementation, treatment effectiveness, and overall iron metabolism health.

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Also Known As: Iron Storage Test

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The Complete Blood Count with Differential and Platelets Test is a comprehensive blood test that checks red blood cells, white blood cells, hemoglobin, hematocrit, and platelets. The differential analyzes types of white blood cells to detect infections, anemia, clotting abnormalities, immune conditions, and certain cancers. This essential test is often ordered for routine health exams, diagnosis, and monitoring treatment progress.

Blood
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Also Known As: CBC Test, CBC with Differential and Platelets Test, CBC w/Diff and Platelets Test, Full Blood Count Test, Complete Blood Count Test

The Comprehensive Metabolic Panel (CMP) Test measures 21 markers to assess metabolic health, liver and kidney function, and electrolyte balance. It includes glucose, calcium, sodium, potassium, chloride, CO2, albumin, globulin, A/G ratio, total protein, bilirubin, ALP, AST, ALT, BUN, creatinine, BUN/creatinine ratio, and eGFR. The CMP helps detect diabetes, liver or kidney disease, and supports routine screening and chronic condition monitoring.

Serum
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Also Known As: CMP Test, Chemistry Panel Test, Chem Test, Chem 21 Test, Chem 14 Test 

The Fecal Globin by Immunochemistry Test detects hidden (occult) blood in stool using antibodies that identify human globin protein. This test helps screen for colorectal cancer, polyps, ulcers, and gastrointestinal bleeding. Doctors order it when patients have anemia, abdominal pain, or changes in bowel habits. Results provide early detection of digestive tract bleeding, guiding further evaluation with colonoscopy or other diagnostic procedures.

Varied
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Also Known As: Fecal Immunochemical Test, Fecal Occult Blood Test, Stool Occult Blood Test, FIT Test, FOBT

The Hepatic Function Panel Test measures liver enzymes, proteins, and bilirubin to assess liver health and function. It includes ALT, AST, ALP, albumin, total protein, and bilirubin levels. Abnormal results may indicate hepatitis, cirrhosis, fatty liver, or bile duct problems. Doctors use this test to investigate jaundice, nausea, abdominal pain, or fatigue and to monitor liver disease, alcohol use, or medication side effects affecting liver function.

Serum
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Also Known As: Liver Function Panel Test, LFT

The Liver Function Panel, also known as a Hepatic Function Panel, measures proteins, enzymes, and bilirubin to assess liver health and function. It helps detect liver disease, monitor liver conditions, and evaluate the effects of medications or other factors on liver performance.

Serum
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Also Known As: Hepatic Function Panel Test, HFP Test

The Iron Total and Total Iron Binding Capacity (TIBC) Test measures iron levels in blood along with the blood’s ability to transport iron. It helps diagnose iron deficiency anemia, iron overload (hemochromatosis), and monitor nutritional or chronic health conditions. Low iron or high TIBC may indicate anemia, while high iron or low TIBC can suggest overload. Doctors use this test to evaluate fatigue, weakness, or other symptoms linked to iron and metabolic health.

Serum
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Also Known As: Serum Iron Test, Total Iron Binding Capacity Test, TIBC Test, UIBC Test

The Iron Micronutrient Test measures blood iron levels to evaluate nutritional status and detect deficiencies or excess. Iron is essential for hemoglobin production, oxygen transport, energy metabolism, and immune function. This test helps identify anemia, iron overload, absorption issues, or dietary imbalances, supporting diagnosis and management of overall health and vital body functions.

Patient must be 18 years of age or older.
Serum
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Also Known As: Serum Iron Test, Serum Fe Test

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The Iron Total Test measures iron levels in blood to evaluate nutritional status, red blood cell production, and overall metabolic health. Abnormal levels may indicate iron deficiency anemia, chronic blood loss, or poor absorption, while high levels may suggest hemochromatosis, liver disease, or iron overload. Doctors use this test to investigate fatigue, weakness, or pallor and to monitor treatment. Results provide key insight into anemia and iron balance.

Serum
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Also Known As: Serum Iron Test, Serum Fe Test

The Mineral Micronutrients Test Panel measures minerals: Calcium, Chromium, Copper, Iron, Magnesium RBC, Manganese, Molybdenum, Selenium, and Zinc to assess nutritional balance and overall health. These minerals are essential for bone strength, metabolism, energy production, antioxidant defense, and immune function. The panel helps detect deficiencies, excesses, or absorption issues, guiding health management.

Patient must be 18 years of age or older.

The Soluble Transferrin Receptor Test evaluates blood sTfR concentration to assess iron metabolism and red blood cell production. It is particularly useful for differentiating iron deficiency anemia from anemia of chronic disease, since sTfR remains stable in the presence of inflammation. This test helps clinicians identify hidden iron deficiency, monitor treatment response, and evaluate hematopoietic activity in various clinical contexts.

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The Zinc Protoporphyrin (ZPP) Test measures ZPP levels in red blood cells to detect iron deficiency and lead exposure. When iron is low or lead interferes with hemoglobin production, ZPP accumulates, making it a sensitive early marker. Doctors use this test to screen for iron-deficiency anemia, monitor occupational lead exposure, and evaluate unexplained anemia, helping guide diagnosis, prevention, and treatment strategies.

Blood
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Also Known As: ZPP Test, ZP Test, Free Erythrocyte Protoporphyrin Test, FEP Test

Blood, Serum
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Hemochromatosis is a disease that causes too much iron to build up in your body, which is problematic because excessive iron damages your organs, especially your liver, your heart, and your pancreas. An estimated one million people in the United States suffer from this condition.

Fortunately, if hemochromatosis is diagnosed early on, it can be treated before serious complications arise. Read on to learn more about this condition, including risk factors, signs and symptoms, and where and how to get hemochromatosis tests.

About Hemochromatosis

There are two types of hemochromatosis, primary and secondary. Primary hemochromatosis is a genetic condition, meaning it is caused by a mutation in your genes. This type of hemochromatosis is passed down from family members.

Secondary hemochromatosis is caused by excessive amounts of iron in your body. This type of hemochromatosis is not as common, and it can't be detected through a hemochromatosis DNA test.

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