Ulta Lab Tests

Proteinase-3 Antibody Test

The Proteinase-3 Antibody Test detects antibodies against proteinase-3, a neutrophil enzyme associated with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Elevated levels are strongly linked to granulomatosis with polyangiitis and other autoimmune small vessel vasculitides. This test aids in diagnosis, assessing disease activity, and guiding management of systemic inflammatory and autoimmune vascular conditions.

Serum
Phlebotomist
There are no preparation instructions.

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Specimen Type: Serum

Also known as: PR-3, Proteinase3 Antibody

Proteinase-3 Antibody

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The Proteinase-3 Antibody Test test contains 1 test with 1 biomarker .

Patients with vascular diseases will generally have either a C-ANCA pattern or P-ANCA pattern, and give positive results in specific tests for PR-3 or MPO. Patients with bowel disease have been shown to have antibodies that give a P-ANCA or C-ANCA pattern. These antibodies however may not be directed towards MPO. Patients with drug induced lupus, etc., often present with a P-ANCA pattern that is associated with antibodies against MPO.

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